Sexuality education is one of the central issues in social life due to its sensitiveness to be discussed in the family or even in the public. There is an increasing concern especially on the teenagers’ healthy sexual life style that is currently become an ardent debate due to the increment of social problems such as baby dumping and HIV/AIDS. This worrisome scenario is believed due to the lack of sexuality education among youth. Hence, this research focuses on the moderating effect of quality of relationship on parenting practices and effective communication on sexuality education among parents and their children in the area of Shah Alam, Rawang and Gombak. A total number of 320 parents responded to this study. The findings of this study revealed that there is a low level of effective communication on sexuality education among parents and children. Further, two dimensions of parenting practices were found significant in this study which were parental solicitation and behaviour management. Finally, quality of relationship was found significant with the behaviour management and effective communication on sexuality education.