The issue pertaining to the quality of life or well-being involving the low-income or poor people has frequently be regarded as worrying especially those who live in urban areas. In Malaysia, this group of people is known as the B40 citizens. The B40 citizens in urban areas are very vulnerable to the economic changes such as the increasing cost of living as they have limited income to spend on the socio-economic aspects such as education, health and living environment as compared to the middle income (M40) and high income group of people (T20). Hence, the main objective of this research is to identify the level of quality of life among B40 citizens at the three low-costs flats in one parliamentary area of Puteri Wangsa in Mukim Tebrau, Johor Bahru based on the determinants of children’s education, family’s health status and residential environment. The unit analysis of this study is the low-income households in the low-costs flats in Johor Bahru. The finding shows that the level of quality of life among the low-income households within the territory of the study is at the moderate level as the average value is 3. While the findings for the relationship between children’s education, family’s health status and residential environment indicates the moderate relationship at positive significant correlation towards the quality of life among B40 citizens in rising cost of living. The findings also shows that, there are moderator effect of income and distribution in the relationship between the children’s education, family’s health status and residential environment towards the quality of life among B40 citizens pertaining to the rising cost of living as the significant p-value is less than 0.05. Last but not least, in order to reduce the problem regarding the quality of life among B40 citizens in the increasing living cost, it is recommended that the government policy and initiatives to be enhanced, added and changed so that the concerns about the poor and vulnerable sections of society are acknowledge and be included in National policies pertaining to the socio-economic aspects.